Fingolimod does not enhance cerebellar remyelination in the cuprizone model
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چکیده
منابع مشابه
Fingolimod does not enhance cerebellar remyelination in the cuprizone model
Fingolimod (FTY720) is approved for treatment of relapsing-remitting multiple sclerosis. In vitro studies have found that fingolimod stimulates remyelination in cerebellar slices, but in vivo animal studies have not detected any positive effect on cerebral remyelination. The discrepant findings could be a result of different mechanisms underlying cerebral and cerebellar remyelination. The cupri...
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The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow. However, since cuprizone is sensitive to the environment and the consumption of it varies between different animals, the major issue is the discrepancy in demyelination of the animals. This ...
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ژورنال
عنوان ژورنال: Journal of Neuroimmunology
سال: 2015
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2015.06.006